Mathematical modelling of cell adhesion forces : from delay to friction, an instantaneous limit.


Vuk Milisic, Université de Paris. 21 mai 2015 11:00 edp 2:00:00
Abstract:

In this talk we present the starting mechanical model of the lamellipodial actin-cytoskeleton meshwork. The model is derived starting from the microscopic description of mechanical properties of laments and cross-links and also of the life-cycle of cross-linker molecules]. We introduce a simplified system of equations that accounts for adhesions created by a single point on which we apply a force. We present the adimensionalisation that led to a singular limit that motivated our mathematical study. Then we explain the mathe- matical setting and results already published. In the last part we present the latest developments : we give results for the fully coupled system with unbounded non-linear o-rate. This leads to two possible regimes : under certain hypotheses on the data there is global existence, out of this range we are able to prove blow-up in nite time.